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An omnivorous diet allows for the B12 intake through animal products (with a bioavailability ranging from 24% to 36% in eggs, up to 65% in lean meat) (Doets et al., 2013), while vitamin B12 is scarce or absent in diets including little or no animal products

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The most commonly used approach is in vitro or ex vivo tests using diffusion cells, or more recently, the parallel artificial membrane permeability assay (Skin-PAMPA) and phospholipid vesicle-based permeation assay (PVPA) (Figure 4) [40], allowing for the quantification of the permeation of CACs through the skin