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However, the opposing polar amino acids that divide the ligand-binding pocket into two cavities in the ghrelin receptor are conserved in the motilin receptor as Glu127 3.33 and Arg337 6.55

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Populations who should not use BPC-157: Pregnant or breastfeeding individuals (no safety data), anyone with a history of cancer (theoretical concern given pro-angiogenic mechanisms), individuals taking anticoagulants (some animal data suggest effects on platelet aggregation pathways), and anyone without access to sterile technique for injection preparation